• Interaction

    AccNo. 50526 Score 0.49
    Name PM_2908009
    Kd 1.0

    Peptide

    AccNo. 50404
    Name YYPLG
    Sequence YYPLG
    50404_small
    Internalized no
    Is Motif no

    Interactor

    AccNo. 50026
    Name unknown

    Experiment

    AccNo. 50368
    Classification incorrect?
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    Voting_motivation
    CA CVD DM APO ANG MI BD
    0.68 0.59 0.42 0.59 0.43 0.04 0.61 Vote
    plus plus plus plus plus plus plus Yes
    minus minus minus minus minus minus minus No
    Name PM_2908009
    Detection unspecified method, MI:0686
    Source Pubmed Text Id 2908009
    Journal Res Commun Chem Pathol Pharmacol. 1988 Nov;62(2):365-8.
    Title Structural specificity of MIF-1 and Tyr-MIF-1 in augmenting GABA-stimulated benzodiazepine receptor binding.
    Authors Miller LG, Kastin AJ, Roy RB, Gaver A, Fischman AJ, Horvath A
    Text The possibility of a linkage between endogenous peptides and the GABA-benzodiazepine system has been greatly strengthened by reports that the brain peptides MIF-1(Pro-Leu-Gly-NH2) and Tyr-MIF-1(Tyr-Pro-Leu-Gly-NH2) augment GABA-stimulated benzodiazepine binding. We evaluated the actions of fragments and analogs of these small peptides on GABA-stimulated benzodiazepine binding in mouse cortical brain membranes. Fragments of Tyr-MIF-1, several compounds related to MIF-1, or several analogs of Tyr-MIF-1 had no effect on binding. These results demonstrate the specificity of the effects of MIF-1 and Tyr-MIF-1 on GABA-stimulated benzodiazepine binding.
    Mesh Terms Animals; Binding Sites/drug effects; Cerebral Cortex/metabolism; MSH Release-Inhibiting Hormone/analogs & derivatives; MSH Release-Inhibiting Hormone/pharmacology; Mice; Receptors, GABA-A/metabolism; Structure-Activity Relationship; gamma-Aminobutyric Acid/pharmacology
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