PepBank

Experiment

AccNo.	21504	processing... Classification incorrect? Click the corresponding button to vote. Your vote is used to improve the automatic classification. CA CVD DM APO ANG MI BD 0.52 0.52 0.50 0.53 0.50 0.51 0.52 Vote Yes No
Name	PD_1
Detection	filamentous phage display, MI:0048

Source	PDF	Text Id	1
Journal	Nat Med. 2002 Feb;8(2):121-7.
Title	Steps toward mapping the human vasculature by phage display.
Authors	Arap W, Kolonin MG, Trepel M, Lahdenranta J, Cardó-Vila M, Giordano RJ, Mintz PJ, Ardelt PU, Yao VJ, Vidal CI, Chen L, Flamm A, Valtanen H, Weavind LM, Hicks ME, Pollock RE, Botz GH, Bucana CD, Koivunen E, Cahill D, Troncoso P, Baggerly KA, Pentz RD, Do KA, Logothetis CJ, Pasqualini R
Text	The molecular diversity of receptors in human blood vessels remains largely unexplored. We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a peptide library. Here we report the first in vivo screening of a peptide library in a patient. We surveyed 47,160 motifs that localized to different organs. This large-scale screening indicates that the tissue distribution of circulating peptides is nonrandom. High-throughput analysis of the motifs revealed similarities to ligands for differentially expressed cell-surface proteins, and a candidate ligand-receptor pair was validated. These data represent a step toward the construction of a molecular map of human vasculature and may have broad implications for the development of targeted therapies.
Mesh Terms	Blood Vessels/physiology; Humans; Oligopeptides/chemistry; Organ Specificity; Peptide Library; Reproducibility of Results; Software; Variation (Genetics)

References