• Interaction

    AccNo. 21573 Score 0.86
    Name AEEGG_fat Environment in vivo
    Kd 1.0 Organism Homo sapiens (human)

    Peptide

    AccNo. 21457
    Name AEEGG
    Organism N/A
    Constraint disulfide
    Sequence AEEGGTS
    21457_small
    Origin phage display
    Form phage
    Internalized no
    Unnatural no
    Imaging no
    Is Motif no

    Interactor

    AccNo. 21309
    Name fat
    Description fat
    Organism Homo sapiens (human)
    Type tissue

    Experiment

    AccNo. 21504
    Classification incorrect?
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    Voting_motivation
    CA CVD DM APO ANG MI BD
    0.57 0.67 0.25 0.75 0.58 0.80 0.60 Vote
    plus plus plus plus plus plus plus Yes
    minus minus minus minus minus minus minus No
    Name PD_1
    Detection filamentous phage display, MI:0048
    Source PDF Text Id 1
    Journal Nat Med. 2002 Feb;8(2):121-7.
    Title Steps toward mapping the human vasculature by phage display.
    Authors Arap W, Kolonin MG, Trepel M, Lahdenranta J, Cardó-Vila M, Giordano RJ, Mintz PJ, Ardelt PU, Yao VJ, Vidal CI, Chen L, Flamm A, Valtanen H, Weavind LM, Hicks ME, Pollock RE, Botz GH, Bucana CD, Koivunen E, Cahill D, Troncoso P, Baggerly KA, Pentz RD, Do KA, Logothetis CJ, Pasqualini R
    Text The molecular diversity of receptors in human blood vessels remains largely unexplored. We developed a selection method in which peptides that home to specific vascular beds are identified after administration of a peptide library. Here we report the first in vivo screening of a peptide library in a patient. We surveyed 47,160 motifs that localized to different organs. This large-scale screening indicates that the tissue distribution of circulating peptides is nonrandom. High-throughput analysis of the motifs revealed similarities to ligands for differentially expressed cell-surface proteins, and a candidate ligand-receptor pair was validated. These data represent a step toward the construction of a molecular map of human vasculature and may have broad implications for the development of targeted therapies.
    Mesh Terms Blood Vessels/physiology; Humans; Oligopeptides/chemistry; Organ Specificity; Peptide Library; Reproducibility of Results; Software; Variation (Genetics)
    References
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